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KMID : 1101220020340020232
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2002 Volume.34 No. 2 p.232 ~ p.237
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Effects of Drinking, Smoking and Exercise on Homocysteine, Folate and C-Reactive Protein Levels in Patients with Coronary Artery Disease
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Hwang Seock-Yeon
Cho Min-Ja
Chang Cheoul-Soo
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Abstract
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This study was carried out to investigate the effects of drinking, smoking and exercise on homocysteine, folate and the C-reactive protein in patients with coronaη artery disease. A total of 50 subjects (male; 37, female; 13) with coronary artery disease was assigned to patient group. The normal control group consisted of 33 subjects (male; 21, female; 12) without a history of metabolic or cardiovascular disease. Body mass index (BMI), blood pressure, and concentration of blood homocysteine, folate, C-reactive protein (CRP) , and lipids were analyzed to determine the effect of drinking, smoking and exercise on those parameters related to coronary artery disease. Concentrations of CRP (p<0.001), total cholesterol (p<0.001), triglyceride (p<0.005), HDLcholesterol (p<0.002) and LDL-cholesterol (p<0.04) were significantly higher in the patient group. It was also shown that one of either homocysteine, folate, or CRP levels has a direct relationship with habit. Among the three habits, smoking played the worst role in folate and CRP levels in the patient group. Homocysteine and CRP (p<0.001) concentrations were increased and the folate concentration (p<0.05) was decreased in the smoking group. These results suggest that smoking makes matters of coronary artery disease worse; therefore, it would be critical for patients with coronary artery disorder to quit smoking.
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KEYWORD
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Homocysteine, Folate, Coronary arteη disease(CAD), CRP
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